TABLE 3

Noncompartmental pharmacokinetic parameters of each enantiomer after intravenous administration of R-IB or S-IB

Results are expressed as the mean ± S.D. (n = 3).

Parameter	Control			AA
Parameter	R-IB after R-IB	S-IB after R-IB	S-IB after S-IB	R-IB after R-IB	S-IB after R-IB	S-IB after S-IB
T_1/2 (min)	33.9 ± 4.5	77.8 ± 24.4	84.2 ± 23.7^{^b}	30.4 ± 5.0	69.8 ± 23.9	56.3 ± 4.8^{^b}
CL_tot (ml/kg)	4.20 ± 0.23	―	1.30 ± 0.18^{^b}	6.20 ± 0.66^{^a}	―	2.40 ± 0.40^{^a}^,^{^b}
MRT (min)	32.8 ± 5.4	―	109.3 ± 30.5^{^b}	26.7 ± 3.1	―	69.6 ± 8.77^{^a}^,^{^b}
Vd_ss (ml/kg)	137 ± 18	―	146 ± 54	164 ± 10	―	168 ± 23
AUC (μg∣min/ml)	2386 ± 129	3549 ± 474	7682 ± 1054^{^b}	1624 ± 171^{^a}	2090 ± 265^a	4129 ± 568^{^a}^,^{^b}

↵^a P < 0.05 compared with controls.
↵^b P < 0.05 compared with its antipode.
The em dashes indicate no value because of unidirectional chiral inversion of IB.