TABLE 1

Similarity of amino acid sequences of three marmoset P450 3A forms compared with P450 3As from other species

P450 FormMarmoset P450
3A4 Ortholog3A5 Ortholog3A90
Human
 3A4908382
 3A5848988
 3A7867978
 3A43767374
Chimpanzee
 3A4908382
 3A5858988
 3A7878079
Orangutan
 3A67878080
 3A43767474
Cynomolgus monkey
 3A4908281
 3A5838988
 3A7877979
 3A43767374
Dog
 3A12787777
 3A26767575
Pig
 3A22757373
 3A29757573
 3A39747573
 3A46757472
Rabbit
 3A6757574
Rat
 3A2717070
 3A9777675
 3A18696968
 3A23717271
 3A62717271
Mouse
 3A11737372
 3A13757574
 3A16696969
 3A25717069
 3A41707170
 3A44696969
 3A57696767
 3A59706968
Marmoset
 3A4 ortholog8482
 3A5 ortholog8496
 3A908296