Concentrations of NIM and its metabolites (M1, M2, and M4) in rat plasma and liver tissue at 24 hours after the last dose of NIM
The rats received oral administration of 100 mg/kg/day NIM for 5 days. Data are reported as the mean ± S.D. (n = 6).
| Metabolites | Concentration | |
|---|---|---|
| Plasma | Liver tissue | |
| μM | ||
| NIM | 45.4 ± 19.4 | 17.3 ± 10.1 |
| M1 | 21.0 ± 1.9 | 23.6 ± 7.6 |
| M2 | 0.037 ± 0.020 | 1.80 ± 0.62 |
| M4 | 0.180 ± 0.113 | 13.4 ± 8.9 |