Simcyp calibrated in vitro CYP3A4 induction parameters for PF-06282999
| PF-06282999 | |||
|---|---|---|---|
| Donor | CYP3A4 mRNA | ||
| Indmax | IndC50 | γ | |
| μM | μM | ||
| HH1089 | 8.98 | 56.0 | 1.25 |
| HC7-4 | 8.44 | 17.9 | 2.20 |
| FOS | 5.86 | 12.0 | 1.99 |
Indmax, maximum fold induction; IndC50, concentration that yields half of the Emax.