TABLE 6

Statistical summary of the pharmacokinetic parameters after an oral dose of 7.5 mg midazolam with and without coadministration of PF-06282999

For each PF-06282999 dose, n = 9 subjects; the ratios (and 90% Cis) are expressed as percentages.

Midazolam Parameter (Adjusted Geometric Mean)Interaction with 125 mg Three Times Daily PF-06282999Interaction with 500 mg Twice Daily PF-06282999
With PF-06282999 (Test)Without PF-06282999 (Reference)Ratio of Test/Reference (90% CI)With PF-06282999 (Test)Without PF-06282999 (Reference)Ratio of Test/Reference (90% CI)
AUC0–inf (h/ng/ml)72.311066.0 (59.0, 73.8)45.410642.9 (38.3, 47.9)
AUC0–16 hours (h/ng/ml)70.010467.4 (60.5, 75.2)44.610243.7 (39.2, 48.7)
Cmax (ng/ml)29.843.169.2 (54.0, 88.6)22.137.558.9 (46.0, 75.4)
  • AUC0–inf, area under the plasma concentration-time curve from zero to infinity; AUC0–16 hours, area under the plasma concentration-time curve from zero to 16 hours; CI, confidence interval.