Midazolam Parameter (Adjusted Geometric Mean) | Interaction with 125 mg Three Times Daily PF-06282999 | Interaction with 500 mg Twice Daily PF-06282999 | ||||
---|---|---|---|---|---|---|

With PF-06282999 (Test) | Without PF-06282999 (Reference) | Ratio of Test/Reference (90% CI) | With PF-06282999 (Test) | Without PF-06282999 (Reference) | Ratio of Test/Reference (90% CI) | |

AUC_{0–inf} (h/ng/ml) | 72.3 | 110 | 66.0 (59.0, 73.8) | 45.4 | 106 | 42.9 (38.3, 47.9) |

AUC_{0–16 hours} (h/ng/ml) | 70.0 | 104 | 67.4 (60.5, 75.2) | 44.6 | 102 | 43.7 (39.2, 48.7) |

C_{max} (ng/ml) | 29.8 | 43.1 | 69.2 (54.0, 88.6) | 22.1 | 37.5 | 58.9 (46.0, 75.4) |

AUC

_{0–inf}, area under the plasma concentration-time curve from zero to infinity; AUC_{0–16 hours}, area under the plasma concentration-time curve from zero to 16 hours; CI, confidence interval.