TABLE 8

Summary of predicted versus observed DDI using Simcyp

Perpetrator DrugVictim DrugPredicted DDI AUCRObserved DDI AUCR
Geometric Mean (90% CI)
PF-6282999 500 mg twice a dayMidazolam 7.5 mg0.62 (0.59–0.65)0.43 (0.38, 0.48)
PF-6282999 125 mg three times a dayMidazolam 7.5 mg0.91 (0.90–0.92)0.66 (0.59, 0.74)