Scenario 1 | Scenario 2 | |
---|---|---|
CLint,u,UGT,HKM (µl/min/mg protein) | 1061 (43%) | |
MPPGK (mg/g kidney) | 11.1a | 28.4 (21%)b |
Scaled CLint,u,UGT,HKM (ml/min/g kidney) | 11.8 (43%) | 30.2 (53%) |
Kidney:liver ratio for scaled CLint,u,UGTc | 1.26 (43%) | 3.24 (53%) |
Kidney weight (g/kg body weight) | 4.5 | 3.1 |
fu,p | 0.01 | 0.01 |
RB | 0.6 | 0.6 |
QR (ml/min/kg) | 16.4 | 13.2 |
Predicted CLR,met,UGT (ml/min/kg) | 0.83 (41%) | 1.35 (47%) |
Kidney: liver ratio for predicted CLmet,UGT | 0.29 (41%) | 0.47 (47%) |
Predicted CLUGT (mL/min/kg)d | 3.70 (9%) | 4.21 (15%) |
Mean predicted/observed CLUGTe | 0.93 (9%) | 1.06 (15%) |
↵a 11.1 mg/g kidney used for all donors, calculated as weighted (by donor number) mean of values recently reported for mixed kidney and unspecified kidney region (Al-Jahdari et al., 2006; Knights et al., 2016).
↵b Donor-specific MPPGK values measured in the current study used.
↵c CLint,u,UGT,HLM was 9.32 ml/min/g liver, which is based on in vitro measurements in the presence of BSA (Gill et al., 2012).
↵d CLh,met,UGT (2.86 ml/min/kg) calculated per Gill et al. (2012).
↵e Observed CLUGT was 3.97 ml/min/kg (Gill et al., 2012).