Physiologic values used for CLR,met,UGT predictions using IVIVE in different scenarios
| Parameter (U) | Scenario 1 (Whole Kidney) | Scenario 2 (Kidney Cortex) |
|---|---|---|
| MPPGK (mg/g kidney) | 11.1a | Donor specificb |
| Kidney weight (g/kg body weight) | 4.5 | 3.1 |
| Renal blood flow (ml/min/kg body weight) | 16.4 | 13.2 |
↵a Weighted (by number of donors) mean of values reported for microsomes prepared from mixed kidney or unspecified region (Al-Jahdari et al., 2006; Knights et al., 2016).
↵b Fig. 5 and (Supplemental Table S3).