TABLE 5

Correlation between in vitro and in vivo Kpuu for humans

CompoundsIn Vivo Liver-to-Plasma KpuuIn Vitro Suspension Hepatocyte Kpuu
Pravastatina2.0 (DHP, PET), 5.3 (PK/PD)2.3 ± 0.2
Rosuvastatinb10 (PK/PD)39 ± 5.0

  • ↵a Pravastatin human fu,p = 0.64 ± 0.16, fu,liver = 0.17 ± 0.02, fu,media = 0.49 ± 0.06.

  • ↵b Rosuvastatin human fu,p = 0.16 ± 0.05, fu,liver = 0.31 ± 0.02, fu,media = 0.19 ± 0.02.