TABLE 3

Bosentan stability, binding, induction parameter estimates, and induction predictions

Hepatocyte Lot	Average % Remaining	f_u,medium	E_max	Nominal EC₅₀	Measured EC₅₀	Nominal EC_50,u	Measured EC_50,u
CDP	33.2	0.38	9.4	1.6	0.7	0.6	0.3
Hu1624	44.1	0.38	11.6	3.0	1.0	1.1	0.4
Prediction method
R₃
CDP			34^a	29.1^b	46.9^b	50.4^b	67.0^b
Hu1624			34^a	21.8^b	44.6^b	41.6^b	65.7^b
AUCR
CDP			34^a	29.4^b	48.2^b	51.9^b	70.1^b
Hu1624			34^a	22.0^b	45.7^b	42.5^b	68.6^b