TABLE 2

K_p,uu,ss and f_T,cell,ss in rat hepatocytes

Values are shown as the mean ± S.D. (n = 3).

Drug	C/M Ratio^{^a}		K_p,uu,ss^{^b}	f_T,cell,ss^{^b}
	37°C	On ice
Diazepam	58.9 ± 7.3	69.3 ± 9.7	0.851 ± 0.024	0.0147 ± 0.0022
Pitavastatin	324 ± 174	29.6 ± 11.5	10.8 ± 4.4	0.0381 ± 0.0167
Rosuvastatin	78.1 ± 37.1	7.80 ± 4.07	13.1 ± 7.7	0.149 ± 0.060
Pravastatin	12.5 ± 7.7	1.80 ± 0.56	6.69 ± 2.76	0.600 ± 0.217

↵^a C/M ratios were calculated using the uptake data at 30 minutes (Fig. 1).
↵^b The K_p,uu,ss and f_T,cell,ss were calculated from C/M ratios using eqs. 2 and 3, respectively.