Physiologic parameter values
| Parameter | Definition | Rat (280 g) | Monkey (6.2 kg) |
|---|---|---|---|
| Vp (ml) | Plasma volume | 9.06 | 187 |
| VECF (ml) | Tissue extracellular fluid volume | 48.72 | 993 |
| QCO (ml/h) | Cardiac plasma output flow | 2945 | 22,433 |
| Qk (ml/h) | Renal plasma flow | 365 | 3237 |
| Vk (ml) | Kidney extracellular fluid volume | 0.361 | 4.09 |
| GFR (ml/h) | Glomerular filtration rate | 78.6 | 624 |
All parameter values except the GFR were obtained from Shah and Betts (2012) and the GFR values were obtained from Davies and Morris (1993).