ka,D (1/h) | Absorption rate constant of DEX | 2.09 | 9.33 |
fd,D | Fraction of cardiac plasma flow of DEX | 1 | Fixed |
CLp Females (ml/h/kg) | Clearance of DEX in female rats | 137.8 | 3.51 |
CLp Males (ml/h/kg) | Clearance of DEX in male rats | 197.7 | 3.43 |
Kp | Tissue partition coefficient of DEX | 0.63 | 4.35 |
Vp (ml/kg) | Plasma volume | 32.36a | Fixed |
Vt (ml/kg) | Tissue volume | 967.6a | Fixed |
VISF (ml/kg) | ISF volume | 173.93a | Fixed |
Qco (ml/h/kg) | Cardiac plasma flow | 7650a | Fixed |
ka,N (1/h) | Absorption rate constant of NPX | 0.98b | Fixed |
fd,N | Fraction of cardiac plasma flow of NPX | 0.15b | Fixed |
CLup (ml/h/kg) | Unbound clearance of NPX in arthritic rats | 1438b | Fixed |