Concentrations of radioactivity in the eyeballs and eyelids of male albino rabbits after ocular administration of 14C-SA22465 at a nominal dose level of 1.5 mg/eye (macroautoradiography)
| Nanograms Equivalents of SA22465/g of Tissue | ||||||||
|---|---|---|---|---|---|---|---|---|
| Animal number and sex | 1, M | 2, M | 3, M | 4, M | 5, M | 6, M | 7, M | 8, M |
| Tissue Sampling time | 1 hour | 4 hours | 8 hours | 24 hours | ||||
| Aqueous humor | 15 | 10 | 11 | BLQ | BLQ | BLQ | BLQ | BLQ |
| Choroid | 38 | 18 | 23 | 12 | 13 | 43 | 19 | BLQ |
| Ciliary body | BLQ | BLQ | BLQ | BLQ | BLQ | BLQ | BLQ | BLQ |
| Cornea | 362 | 294 | 243 | 205 | 213 | 590 | 406 | 176 |
| Iris | BLQ | BLQ | 10 | BLQ | BLQ | BLQ | 12 | BLQ |
| Lens | 13 | BLQ | BLQ | BLQ | BLQ | BLQ | BLQ | BLQ |
| Optic nerve | 87 | 278 | 10 | 14 | 57 | 156 | BLQ | 231 |
| Pupil | 11 | BLQ | BLQ | BLQ | 18 | BLQ | BLQ | BLQ |
| Retina | 37 | BLQ | 18 | 15 | 20 | 18 | BLQ | 20 |
| Sclera | 93 | BLQ | 20 | 15 | 20 | 50 | BLQ | 21 |
| Vitreous humor | BLQ | BLQ | BLQ | BLQ | BLQ | BLQ | BLQ | BLQ |
| Lower eyelid | 32,928 | 3609 | 9290 | 12,575 | 33,673 | 5607 | 15,330 | 27,629 |
| Meibomian gland | ND | ND | ND | ND | ND | ND | ND | ND |
| Skin | ND | ND | ND | ND | ND | ND | ND | ND |
| Upper eyelid | 7,033 | 2,655 | 462 | 3,967 | 192 | 1,084 | 351 | 952 |
BLQ, tissue concentration below lower limit of quantification; ND, not discernible.
Upper limit of quantification: 36,040 ng equiv/g for all measurements
Lower limit of quantification: 9 ng equiv/g for all measurements