TABLE 2

P_app values from in vitro studies and the estimated CL_PD,u

The predicted theophylline maternal f_u,p is 0.66 at term. The predicted zidovudine maternal f_u,p is ∼0.80 at term. The estimated CL_PD,u values were based on mean P_app from in vitro reports.

Drug	P_app Value (nm × s⁻¹)				CL_PD,u (L/h)	Resources
Drug	Mean	S.D.	Median	Range	CL_PD,u (L/h)	Resources
Midazolam	489.9	158.7	490.0	320–699	500.0	(Yamashita et al., 2000; Mahar Doan et al., 2002; Taub et al., 2002; Tolle-Sander et al., 2003; Gertz et al., 2010)
Theophylline	335.5	162.2	260.0	231–620	342.4	(Yamashita et al., 2000; Masungi et al., 2004; Collett et al., 2008; Teksin et al., 2010; Di et al., 2011)
Zidovudine	212.4	217.2	69.3	31.8–543.3	216.8	(Yazdanian et al., 1998; Irvine et al., 1999; de Souza et al., 2009)