Basal gene expression in the liver of PXR (+/+) and PXR (−/−) mice
Results are reported relative to control wild-type PXR (+/+). Data are presented as percentage of mean ± S.E.M. (n = 5–8), where *significant from saline control, *P < 0.05 ***P < 0.001.
| Cytokines/Genes | PXR (+/+) | PXR (−/−) |
|---|---|---|
| Proinflammatory cytokines | ||
| IL-6 | 100 ± 8 | 194 ± 6*** |
| IL-1β | 100 ± 5 | 135 ± 9*** |
| TNF-α | 100 ± 6 | 36 ± 2*** |
| iNOS | 100 ± 9 | 105 ± 4 |
| Socs3 | 100 ± 5 | 509 ± 17*** |
| ABC transporters | ||
| Abcb1a | 100 ± 3 | 34 ± 5*** |
| Abcb1b | 100 ± 4 | 22 ± 2*** |
| Abcg2 | 100 ± 9 | 210 ± 6*** |
| Abcc2 | 100 ± 10 | 55 ± 4*** |
| Abcc3 | 100 ± 15 | 119 ± 8 |
| Abcb11 | 100 ± 6 | 41 ± 1*** |
| SLC transporters | ||
| Slc10a1 | 100 ± 8 | 160 ± 9*** |
| Slco1a4 | 100 ± 6 | 3 ± 1*** |
| Slco2b1 | 100 ± 8 | 128 ± 7* |
| Metabolic enzyme | ||
| Cyp3a11 | 100 ± 4 | 193 ± 9*** |
ABC, ATP-binding cassette; iNOS, inducible nitric oxide synthase.