P450 Gene | WT | PXR−/− | CAR−/− | PXR−/−/CAR−/− |
---|---|---|---|---|
Cyp2b2 | 2.42* | 1.65 | 26.76 | 1.09 |
(± 0.85) | (± 0.50) | (± 23.56) | (± 0.35) | |
Cyp3a23/3a1 | 5.30* | 1.23** | 8.08 | 1.24** |
(± 1.32) | (± 0.27) | (± 4.60) | (± 0.29) | |
Cyp3a18 | 3.78* | 1.19** | 4.86* | 1.19** |
(± 1.23) | (± 0.24) | (± 2.22) | (± 0.13) | |
Cyp3a2 | 2.83* | 1.25 | 2.58* | 0.82 |
(± 2.23) | (± 0.36) | (± 0.70) | (± 0.35) | |
Cyp3a9 | 2.89* | 4.31* | 2.07 | 1.24 |
(± 0.84) | (± 2.03) | (± 1.06) | (± 0.33) | |
Slco1a2 | 3.30* | 1.00** | 3.82* | 0.93** |
(± 1.13) | (± 0.20) | (± 1.01) | (± 0.15) | |
Slco1a1 | 1.34 | 0.81 | 0.65 | 0.64 |
(± 0.55) | (± 0.37) | (± 0.08) | (± 0.13) | |
Slc10a1 | 1.06 | 1.06 | 0.94 | 0.85 |
(± 0.36) | (± 0.21) | (± 0.25) | (± 0.14) | |
Ugt2b1 | 1.87 | 0.68 | 3.65*,** | 0.62 |
(± 0.62) | (± 0.18) | (± 0.97) | (± 0.17) | |
Ugt1a6 | 0.70 | 0.68 | 0.79 | 0.43 |
(± 0.24) | (±0.13) | (± 0.21) | (± 0.07) | |
Sult2a2 | 5.71* | 0.67** | 5.04* | 0.43** |
(± 1.91) | (± 0.18) | (± 1.35) | (± 0.12) | |
Ephx1 | 1.24 | 0.80 | 0.84 | 0.43 |
(± 0.42) | (± 0.16) | (± 0.22) | (± 0.07) | |
Gstm4 | 0.82 | 0.70 | 0.64 | 0.93 |
(± 0.28) | (± 0.14) | (± 0.17) | (± 0.15) |
* P < 0.05, significantly different from vehicle treated, same genotype (t test); **P < 0.05, significantly different from WT (Tukey’s).