Comparison of mean (n = 3) fold of induction of CYP2C9 and CYP3A4 mRNA in vitro in human hepatocytes with reduction in S-warfarin or phenytoin AUC in vivo
| Compound (10 μM) | 2C9 | 3A4 | 2C9% AUC ↓ |
|---|---|---|---|
| Rifampicin | 3 (0.7) | 15 (6) | 74.4a |
| Bosentan | 3 (0.5) | 13 (3) | 29.3a |
| Ritonavir | 2.6 (0.2) | 10 (3) | 24.3a |
| Dalcetrapibb | 2.4 (0.3) | 7.4 (2.5) | 14a |
| Vigabitran | 1.3 (0.2) | 1.4 (0.1) | 3.7c |
↵a Decrease in S-warfarin AUC.
↵b 100 μM.
↵c Phenytoin AUC.
Change in AUC data obtained from the University of Washington Drug-Drug Interaction Database (https://www.druginteractioninfo.org/).