Summary of enzyme activity data for seven UGT enzymes in human liver microsomal samples (n = 59)
| Enzyme | Probe Substrate | Monitored Metabolite | UGT Activity Rates | |
|---|---|---|---|---|
| Mean ± S.D. (%CV) | Range (fold difference) | |||
| nmol min−1 mg−1 HLM protein | ||||
| UGT1A1 | β-estradiol | β-estradiol-3-glucuronide | 0.895 ± 0.648 (72%) | 0.166– 4.173 (25) |
| UGT1A3 | Chenodeoxycholic acid (CDCA) | CDCA-24-glucuronide | 14.980 ± 5.978 (40%) | 4.480–34.222 (8) |
| UGT1A4 | Trifluoperazine | Trifluoperazine-N-glucuronide | 0.414 ± 0.155 (37%) | 0.175–0.856 (5) |
| UGT1A6 | 5-hydroxytryptophol | 5-hydroxytryptophol-O-glucuronide | 19.830 ± 5.924 (30%) | 8.860–38.200 (4) |
| UGT1A9 | Propofol | Propofol-O-glucuronide | 2.296 ± 0.825 (36%) | 0.779–5.013 (6) |
| UGT2B7 | Zidovudine | zidovudine-5′-glucuronide | 1.130 ± 0.344 (30%) | 0.559–2.307 (4) |
| UGT2B15 | S-oxazepam | S-oxazepam glucuronide | 0.143 ± 0.072 (50%) | 0.057–0.395 (7) |