TABLE 1
A list of model state variables used in the differential equations and their definitions
| Variable Name | Definition |
|---|---|
| MMMAE | Amount of MMAE in the media space |
 | Number of molecules of unbound (free) MMAE in a single tumor cell |
| MMAEb | Number of tubulin-bound MMAE molecules in a single tumor cell |
 | Concentration of T-vc-MMAE in the media space |
 | Number of T-vc-MMAE molecules bound on HER2 receptors on a single cell |
 | Number of T-vc-MMAE molecules internalized in endosomal/lysosomal space |
 | Average number of MMAE molecules conjugated to trastuzumab |
 | Number of cells in culture flask |