TABLE 1

Induction parameters, RF_RIF, and RF_PB of 10 inducers for three lots of human hepatocytes

E_max and EC₅₀ were estimated by a simple E_max model with WinNonlin 7.0 (Certara, Princeton, NJ).

Inducer	Donor 1				Donor 2				Donor 3
Inducer	E_max	EC₅₀	RF_RIF	RF_PB	E_max	EC₅₀	RF_RIF	RF_PB	E_max	EC₅₀	RF_RIF	RF_PB
RIF	9.36	0.189	1	790	11.4	0.0961	1	5100	3.71	0.543	1	1160
CRB	10.7	80.7	0.00836	6.60	11.9	47.5	0.00099	5.04	3.75	52.4	0.0089	10.4
PNT	6.18	9.3	0.0246	19.4	12.0	39.4	0.00491	25.0	15.9	291	0.0125	14.5
EFV	36.7	50.0	0.0841	66.4	25.5	15.5	0.126	640	5.88	7.57	0.132	153
PLC	3.91	11.9	0.0175	13.8	7.45	36.7	0.00127	6.47	1.98	2.43	0.0397	46.1
SLF	18.0	68.0	0.0131	10.4	6.14	6.62	0.00404	20.6	5.84	21.5	0.0291	33.7
DXM	13.2	9.21	0.0350	27.6	19.2	19.9	0.00579	29.5	6.54	14.0	0.0950	110
NFD	16.9	150	0.00696	5.49	6.47	12.7	0.0190	96.8	2.26	4.32	0.213	247
PB	9.71	179	0.00127	1	18.1	396	0.00020	1	21.1	5000	0.00086	1
OMP	9.96	31.0	0.00295	2.33	13.3	30.9	0.00197	10.0	6.06	14.1	0.0904	105