TABLE 1

Accuracy and precision of in vivo CLint,u predictions in human and rat hepatocytes and liver microsomes

Data represented by AFE, average fold underprediction, RMSE, and percentage of predictions that fall within, above, and below 2-fold of observed in vivo CLint,u; n = number of drugs.

ParameterHumanRat
HepatocytesMicrosomesHepatocytesMicrosomes
n1018312871
AFE0.240.360.210.43
Average fold underprediction4.22.84.72.3
RMSE3548352436,20363,280
Predictions within 2-fold of observed (%)24252030
Predictions more than 2-fold above observed (%)715914
Predictions more than 2-fold below observed (%)69607156