TABLE 2

Accuracy and precision of in vivo CLint,u predictions in fresh and cryopreserved human hepatocytes

Data represented by AFE, average fold underprediction, RMSE, and percentage of predictions that fall within, above, and below 2-fold of observed in vivo CLint,u. Analyses of the complete data set and a reduced data set of common drugs only are presented; n = number of compounds.

ParameterComplete Data SetCommon Drugs
FreshCryopreservedFreshCryopreserved
n52934343
AFE0.250.230.250.22
Average fold underprediction3.94.34.04.5
RMSE28913013390395
Predictions within 2-fold of observed (%)29222626
Predictions more than 2-fold above observed (%)8672
Predictions more than 2-fold below observed (%)63726772