Average individual ESF for predicted CLint,u according to level of observed CLint,u for human and rat hepatocytes and liver microsomes
| Observed CLint,u | ESF | |||||||
|---|---|---|---|---|---|---|---|---|
| Human | Rat | |||||||
| Hepatocytes | Microsomes | Hepatocytes | Microsomes | |||||
| Log Average | n | Log Average | n | Log Average | n | Log Average | n | |
| ml/min/kg | ||||||||
| <10 | 0.61 | 21 | 0.70 | 17 | 0.13 | 3 | 0.086 | 3 |
| 10–100 | 3.9 | 32 | 1.8 | 20 | 1.6 | 12 | 0.83 | 8 |
| 100–1000 | 7.1 | 40 | 4.6 | 34 | 3.2 | 67 | 1.7 | 34 |
| 1000–10,000 | 22 | 6 | 7.5 | 10 | 7.2 | 37 | 2.5 | 20 |
| >10,000 | 1200 | 2 | 58 | 2 | 180 | 9 | 230 | 6 |