DPGs differentially regulated by the lack of gut microbiome and by PBDEs in livers of CV and GF mice treated with corn oil, BDE-47 (100 μmol/kg), or BDE-99 (100 μmol/kg). CV, conventional mice; GF, germ-free mice; CO, corn oil.
| Category | Treatment | Phase I | Phase II | Transporter |
|---|---|---|---|---|
| A. Genes differentially regulated by gut microbiome (CVCO vs. GFCO) | Corn oil | Cyp1a2, Cyp2b9, Cyp2b13, Cyp2c (2c40, 2c50, 2c54, 2c67, 2c68, 2c69, 2c70), Cyp2e1, Cyp2g1, Cyp2j9, Cyp3a (3a11, 3a16, 3a41a, 3a41b, 3a44, 3a59) | Sult1a1, Sult1b1, Papss2, Gstm2, Gstm6 | Abcb1a, Abcc10 |
| B. Genes differentially regulated by PBDEs only in CV mice (gut microbiome–dependent effect) | BDE-47 | Cyp1a2, Cyp2c39, Cyp2d13, Cyp2g1, Cyp2j9 | Ugt2b1, Ugt2b5, Sult5a1, Gstm2, Gstp1, Gstp2 | Abcb1b, Abcc3, Abcc4, Abcc10 |
| BDE-99 | Cyp2a22, Cyp2c39, Cyp2g1, Cyp2r1, Cyp3a13 | Ugt2b37, Sult2a7 | ||
| C. Genes differentially regulated by PBDEs preferably in GF mice (augmentation effect due to the lack of gut microbiome) | BDE-47 | Cyp2a4, Cyp2a22, Cyp2b9, Cyp2b13, Cyp2c37, Cyp2c54, Cyp3a11, Cyp3a16, Cyp3a41a, Cyp3a41b, Cyp3a44 | Sult2a2, Gsta2, Gstm3, Gstt3 | Slco1a4 |
| BDE-99 | Cyp1a1, Cyp1a2, Cyp2a4, Cyp2a5, Cyp2b10, Cyp2c (2c37, 2c40, 2c50, 2c54, 2c55, 2c69), Cyp2d (2d11, 2d12, 2d13, 2d34, 2d40), Cyp2j9, Cyp3a (3a16, 3a25, 3a41a, 3a41b, 3a44, 3a59) | Ugt2b1, Ugt2b35, Ugt2b38, Ugdh, Ugp2, Sult1d1, Sult1e1, Papss2, Gsta1, Gsta2, Gstm2, Gstm3, Gstt3, Gclc | Slco1a4, Slco1b2, Slco2a1, Abcc2, Abcc10 |