Test Compound | tmax | Cmax | AUC0-t | AUC0-inf | AUCextrap | Kel | t1/2el | MRT |
---|---|---|---|---|---|---|---|---|
h | μg/ml | μg.h/ml | μg.h/ml | % | /h | h | h | |
BIA 9-1079 | ||||||||
Plasma | 0.03 | 52.78 | 84.08 | 84.94 | 1.02 | 0.13 | 5.39 | 2.46 |
Brain | 0.08 | 0.096 | 0.017 | NC | NC | 0.66 | 1.05 | 0.23 |
Tolcapone | ||||||||
Plasma | 0.03 | 67.12 | 36.24 | 36.28 | 0.10 | 0.51 | 1.36 | 1.09 |
Brain | 0.03 | 0.205 | 0.056 | 0.057 | 1.79 | 1.53 | 0.45 | 0.38 |
AUCextrap, extrapolated area under the concentration-time curve; AUC0-inf, area under the concentration-time curve from time zero to infinite; AUC0-t, area under the concentration-time curve from time zero to the last measurable concentration; Kel, apparent elimination rate constant; MRT, mean residence time; NC, not calculated; t1/2el, apparent terminal elimination half-life; tmax, time to achieve the maximum concentration.