TABLE 3

Pharmacokinetic parameters of BIA 9-1079 and tolcapone in plasma and brain after intravenous administration (10 mg/kg) to Wistar rats

The C_max values are expressed in micrograms/gram and the AUC is expressed in micrograms.hour/gram in brain tissue.

Test Compound	t_max	C_max	AUC_0-t	AUC_0-inf	AUC_extrap	K_el	t_1/2el	MRT
	h	μg/ml	μg.h/ml	μg.h/ml	%	/h	h	h
BIA 9-1079
Plasma	0.03	52.78	84.08	84.94	1.02	0.13	5.39	2.46
Brain	0.08	0.096	0.017	NC	NC	0.66	1.05	0.23
Tolcapone
Plasma	0.03	67.12	36.24	36.28	0.10	0.51	1.36	1.09
Brain	0.03	0.205	0.056	0.057	1.79	1.53	0.45	0.38

AUC_extrap, extrapolated area under the concentration-time curve; AUC_0-inf, area under the concentration-time curve from time zero to infinite; AUC_0-t, area under the concentration-time curve from time zero to the last measurable concentration; K_el, apparent elimination rate constant; MRT, mean residence time; NC, not calculated; t_1/2el, apparent terminal elimination half-life; t_max, time to achieve the maximum concentration.