Simcyp model–predicted PK parameters of panobinostat administered as a single oral 20-mg dose on day 7 with and without RIF 600 mg orally dosed once a day for 14 days
| PK Parametera | Panobinostat Alone | Panobinostat + RIF | Geometric Mean Ratio (90% CI) | |
|---|---|---|---|---|
| Cmaxa ng/ml | Predicted (n = 100) | 9.67 (146) | 4.34 (149) | 0.45 (0.41–0.49) |
| AUC0-∞ ng × h/ml | Predicted (n = 100) | 231 (47) | 80.1 (63) | 0.35 (0.320–.38) |
↵a Values are the geometric mean (CV%).