Metabolic AUC ratio of losartan in CYP2C9 polymorphic subjects
Data are presented as mean (S.D., n).
| Group | Genotype | Plasma AUC Ratio | Urine AUC Ratio |
|---|---|---|---|
| Control | Reference Sequence(CC/AA) | 2.45 (1.73, 9) | 0.58 (0.25, 8) |
| CYP2C9*2(CT/AA) | 1.23 (0.56, 4) | 0.51 (0.21, 4) | |
| CYP2C9*3(CC/AC) | 1.53 (0.84, 4) | 0.67 (0.27, 4) | |
| Steatosis | Reference Sequence(CC/AA) | 2.68 (1.94, 6) | 0.53 (0.11, 6) |
| CYP2C9*3(CC/AC) | 0.19 (NA, 1) | 0.13 (NA, 1) | |
| NASH | Reference Sequence(CC/AA) | 0.80 (0.53, 4) | 0.54 (0.14, 4) |
| CYP2C9*2(CT/AA) | 2.06 (NA, 1) | 0.35 (NA, 1) |
NA, not applicable.