TABLE 3 

Metabolic AUC ratio of omeprazole in CYP2C19 polymorphic subjects

Data are presented as mean (S.D., n).

GroupGenotypePlasma AUC RatioUrine AUC Ratio
ControlReference Sequence(GG/CC)1.24 (0.46, 10)51.00 (55.19, 10)
CYP2C19*2(GA/CC)0.63 (0.20, 3)8.56 (9.25, 3)
CYP2C19*17(GG/CT)0.54 (0.47, 2)43.54 (38.39, 2)
CYP2C19*17(GG/TT)0.87 (NA, 1)17.14 (NA, 1)
CYP2C19*2&CYP2C19*17(GA/CT)1.64 (NA, 1)26.18 (NA, 1)
SteatosisReference Sequence(GG/CC)0.55 (0.51, 5)38.05 (37.71, 6)
CYP2C19*2(GA/CC)0.49 (N/A, 1)49.46 (NA, 1)
NASHReference Sequence(GG/CC)0.24 (0.19, 4)17.51 (17.02, 4)
CYP2C19*17(GG/CT)1.97 (NA, 1)23.45 (NA, 1)
  • NA, not applicable.