TABLE 4 

Metabolic AUC ratio of midazolam in CYP3A4 polymorphic subjects

Data are presented as mean (S.D., n).

GenotypePlasma AUC RatioUrine AUC Ratio
ControlReference Sequence(AA)3.84 (1.15, 14)20.48 (10.66, 14)
CYP3A4*1b(AG)3.36 (0.71, 2)10.24 (NA, 1)
SteatosisReference Sequence(AA)3.56 (0.48, 4)16.97 (11.35, 4)
CYP3A4*1b(AG)2.46 (0.41, 3)24.90 (5.54, 3)
NASHReference Sequence(AA)2.45 (0.89, 4)20.61 (8.85, 4)
CYP3A4*1b(AG)1.63 (NA, 1)15.22 (NA, 1)
  • NA, not applicable.