CYP1A2 | CYP2A | CYP2B1 | CYP2B2 | CYP2C6 | CYP2C11 | CYP2D | CYP3A1 | CYP3A2 | ||
---|---|---|---|---|---|---|---|---|---|---|
CMS | Activity | No change | (↓) | ↓ | No change | No change | no change | ↓ | ||
Protein | (↓) | ↓ | ↑ | ↓ | ||||||
mRNA | (↑) | (↑) | No change | No change | No change | |||||
Lurasidone (vs. nonstressed control) | Activity | No change | No change | (↓) | No change | ↓ | No change | No change | ||
Protein | ↓ | ↓ | ↑ | No change | ||||||
mRNA | ↑ | No change | No change | ↑ | ↑ | |||||
CMS + Lurasidone (vs. stressed control) | Activity | (↑) | No change | ↑ | No change | ↓ | No change | ↑ | ||
Protein | (↑) | No change | ↑ | No change | ||||||
mRNA | (↓) | No change | No change | ↑ | ↑ |