Effects of BBR and 6-F-BBR, 6-Cl-BBR, and 6-Br-BBR on SUA levels in oxonate-induced hyperuricemic rats (mean ± S.D., n = 8)
| Group | Dose | SUA | |
|---|---|---|---|
| 7 Days | 8 Days | ||
| mg/kg | |||
| Normal control | 76.4 ± 6.2 | 75.4 ± 4.6 | |
| Hyperuricemic control | 74.7 ± 4.8 | 254.1 ± 21.2a | |
| Hyperuricemic BBR treated | 10 | 54.4 ± 9.5a | 172.2 ± 20.8d |
| Hyperuricemic 6-F-BBR treated | 10 | 59.8 ± 6.2a | 186.4 ± 14.7d |
| Hyperuricemic 6-Cl-BBR treated | 10 | 63.7 ± 6.1b,c | 222.4 ± 18.4c,e,f |
| Hyperuricemic 6-Br-BBR treated | 10 | 64.3 ± 5.5b,c | 215.6 ± 25.8c,e,g |
↵a Compared with normal control group: P < 0.001.
↵b Compared with hyperuricemic control group: P < 0.001.
↵c Compared with normal control group: P < 0.01.
↵d Compared with BBR-treated group: P < 0.05.
↵e Compared with hyperuricemic control group: P < 0.01.
↵f Compared with hyperuricemic 6-F-BBR group: P < 0.001.
↵g Compared with hyperuricemic 6-F-BBR group: P < 0.05.