TABLE 1

Estimates of [3H]-RSV hepatobiliary CLs in SCRHs in the presence of unlabeled RSV (0.5 µM or 1 mM)

Data are the mean ± S.D. of six lots (in the presence of 0.5 µM unlabeled RSV) or five lots (in the presence of 1 mM unlabeled RSV) of SCRH.

CL
0.5 µM1 mM
µl/min per milligram protein
Embedded Image27.7 ± 7.182.14 ± 0.49*
Embedded Image0.56 ± 0.401.86 ± 0.95*
Embedded Image0.32 ± 0.24a0 (fixed)b
Embedded Image32.1 ± 14.2
Embedded Image142 ± 70
Embedded Image0.097 ± 0.062c
Embedded Image (min−1)0.108d

  • ↵a Embedded Image in the presence of 0.5 µM unlabeled RSV was detected in only three lots of SCRHs.

  • ↵b Embedded Image in the presence of 1 mM unlabeled RSV was virtually zero and therefore could not be estimated. Consequently, this value was fixed as 0.

  • ↵c Embedded Image could be estimated in only five lots of SCRHs.

  • ↵d Embedded Image could be estimated in only two lots of SCRHs; therefore, only the mean values of Embedded Image are shown.

  • ↵* P < 0.05 significantly different from the CL in the presence of 0.5 µM CL.