Geometric mean 4βHC plasma levels at each time point
| Negative Control (n = 20) | Positive Control (n = 20) | Midostaurin (n = 10; 4 males and 6 females) | |
|---|---|---|---|
| GM 4βHC plasma levels, CV % (ng/ml) | |||
| Baseline (day 1) | 25.3 (35.5) | 22.0 (44.0) | 29.2 (43.7) |
| Day 3 | N.A. | N.A. | 34.1 (43.7) |
| Day 8 | N.A. | N.A. | 41.7 (39.1) |
| Day 9 | 23.4 (36.4) | 75.0 (32.1) | N.A. |
| Day 11 | 25.4 (35.9) | 89.5 (33.5) | N.A. |
| Day 15 | 23.3 (38.8) | 102.7 (27.6) | 53.8 (34.7) |
| Day 22 | N.A. | N.A. | 51.4 (37.1) |
| Day 28 | N.A. | N.A. | 56.0 (35.6) |
| GM percentage change in 4βHC plasma levels from baseline, CV % (%) | |||
| Day 3 | N.A. | N.A. | 16.8 (0.1) |
| Day 8 | N.A. | N.A. | 42.9 (−10.3) |
| Day 9 | −7.7 (102) | 240.3 (−26.9) | N.A. |
| Day 11 | 0.4 (101) | 306.0 (−23.9) | N.A. |
| Day 15 | −8.1 (109) | 366.1 (−37.3) | 84.2 (−20.6) |
| Day 22 | N.A. | N.A. | 76.1 (−14.9) |
| Day 28 | N.A. | N.A. | 91.7 (18.4) |
N.A., not applicable.