Kinetic parameters of clopidogrel carboxylic acid (0.5 µM) depletion in HLMs, HIMs, and human recombinant UGT2B7 and UGT2B17 at protein concentration of 0.4 mg⋅ml−1
| HLM | HIM | UGT2B7 | UGT2B17 | |
|---|---|---|---|---|
| kdep (1⋅min−1) | 0.00215 | 0.00151 | 0.000405 | 0.000718 |
| CLint,u,dep (µl⋅min−1⋅mg−1) | 5.38 | 3.77 | 3.35 | 1.80 |
| CLint,in vivo (ml⋅min−1⋅kg−1) | 5.53 | NA | NA | NA |
NA, not applicable.