Observed and predicted toxicokinetic parameters of DA in monkeys after single intravenous doses
Observed values are reported as geometric mean ± S.D. The predicted population representative values simulated using the PBPK model are shown together with the predicted range of values included in parentheses.
| PK Parameter | Observed 5 µg/kg intravenously | Predicted 5 µg/kg intravenously | Observed 50 µg/kga intravenously | Predicted 50 µg/kg intravenously |
|---|---|---|---|---|
| AUC0–∞ [(h⋅ng)/ml] | 40 ± 24 | 40 (23–58) | 700 ± 334 | 403 (230–578) |
| CL [(ml/h)/kg] | 124 ± 71 | 124 (87–218) | 73 ± 33 | 124 (87–218) |
| CLR [(ml/h)/kg] | 36 ± 30 | 59 (21–152) | 56 ± 35 | 59 (21–152) |
| t1/2 (hours) | 1.2 ± 1.1 | 0.8 (0.5–1.2) | 1.7 ± 1.0 | 0.8 (0.5–1.2) |
| Vss (ml/kg) | 131 ± 71 | 149 | 165 ± 17 | 149 |
↵a Data from Truelove and Iverson.(1994).