TABLE 3ā€ƒ

Enriched biologic processes after incubation of PHHs with CITCO

GO NumberBiologic ProcessCountP ValueGenes
Deregulated by CITCO in the absence of EGF only
GO.0042738Exogenous drug catabolic process61.09eāˆ’05CYP1A2, CYP2A7, CYP2C19, CYP2C8, CYP2C9, CYP3A4
GO.0016098Monoterpenoid metabolic process44.66eāˆ’05CYP1A2, CYP2C19, CYP2C9, CYP3A4
GO.0019373Epoxygenase P450 pathway50.000103CYP1A2, CYP2A7, CYP2C19, CYP2C8, CYP2C9
GO.0042221Response to chemical410.000103ADCY2, AKR1B1, ANXA3, CA3, CPEB3, CREB3L3, CTGF, CXCL5, CYP1A2, CYP2A7, CYP2C19, CYP2C8, CYP2C9, CYP3A4, CYP3A43, CYP3A7, EPHX1, ETV1, F2R, GSTA1, IL18, ITGA2, KCNA5, KRT19, MATN2, MICALL1, MRC1, MYL9, OR1C1, OR51B4, PANX1, PF4V1, POR, SERPINE1, SLC23A1, SOCS2, SOX2, TGFB2, TMEM67, TNFSF11, WNT6
GO.0050896Response to stimulus580.000166ADCY2, AK7, AMOTL1, ANO1, BOC, CA3, CPE, CPEB3, CRIM1, CXCL5, CYP1A2, CYP2A7, CYP2C19, CYP2C8, CYP2C9, CYP3A4, CYP3A43, CYP3A7, DKK3, DST, EPHX1, ETV1, F2R, GSTA1, HRH4, IL18, ITGA2, KCNA5, KRT19, LRRN4, MAP4K5, MATN2, MCTP2, MICALL1, MRC1, MYL9, NABP1, OR1C1, OR51B4, PF4V1, PLK2, PNMA1, POR, RASEF, RRAD, RRM1, SERPINE1, SLC23A1, SOCS2, STK17A, SUSD4, TACSTD2, TGFB2, TMEM67, TNC, TNFSF11, VSIG4, WNT6
GO.0097267Omega hydroxylase P450 pathway40.000166CYP1A2, CYP2C19, CYP2C8, CYP2C9
GO.0006805Xenobiotic metabolic process90.000299CYP1A2, CYP2A7, CYP2C19, CYP2C8, CYP2C9, CYP3A4, CYP3A43, CYP3A7, GSTA1
GO.0071466Cellular response to xenobiotic stimulus90.00033CYP1A2, CYP2A7, CYP2C19, CYP2C8, CYP2C9, CYP3A4, CYP3A43, CYP3A7, GSTA1
GO.0070989Oxidative demethylation40.00102CYP1A2, CYP2C8, CYP2C9, CYP3A4
GO.1901700Response to oxygen-containing compound200.00389ADCY2, AKR1B1, CA3, CPEB3, CTGF, CXCL5, CYP1A2, F2R, IGFBP1, IL18, KCNA5, MRC1, PANX1, PAX2, PF4V1, POR, SERPINE1, SOCS2, TGFB2, WNT6
Deregulated by CITCO in the presence of EGF only
GO.0006397mRNA processing90.00486DHX9, HNRNPC, MBNL2, RBM22, RBM27, SON, SRRM2, SYNCRIP, THRAP3
GO.0048255mRNA stabilization40.00486DHX9, HNRNPC, SYNCRIP, THRAP3
GO.0016071mRNA metabolic process100.00533DHX9, EIF4G1, HNRNPC, MBNL2, RBM22, RBM27, SON, SRRM2, SYNCRIP, THRAP3
GO.0008380RNA splicing80.0061DHX9, HNRNPC, MBNL2, RBM22, SON, SRRM2, SYNCRIP, THRAP3
  • IGF, insulin-like growth factor.