TABLE 5 

List of genes differentially regulated by CITCO and PB in a CAR-dependent manner

siCTsiCAR
−EGF+EGF−EGF+EGF
CITCOPBCITCOPBCITCOPBCITCOPB
FCq-valueFCq-valueFCq-valueFCq-valueFC*q-valueFC**q-valueFC*q-valueFC**q-value
TAGLN0.60.00.60.01.47.51.1N.S.1.40.0N.S.N.S.N.S.
RDH161.30.01.40,00.9N.S.1.1N.S.0.70.0N.S.N.S.N.S.
ALAS11.40.03.30.01.1N.S.2.30.00.70.0N.S.N.S.N.S.
POR1.50.02.60.01.1N.S.2.40.00.70.0N.S.N.S.N.S.
CYP2C91.50.01.80.01.1N.S.1.80.00.70.0N.S.0.75.3N.S.
CPEB31.60.02.70.01.0N.S.1.3N.S.0.70.0N.S.N.S.N.S.
CYP2C81.70.02.30.01.1N.S.3.70.00.70.0N.S.N.S.N.S.
CYP3A431.90.05.40.01.0N.S.2.30.70.60.0N.S.N.S.N.S.
EPHX12.10.02.30.01.3N.S.1.70.40.60.0N.S.N.S.N.S.
TSKU2.40.03.80.01.2N.S.3.10.00.50.0N.S.N.S.N.S.
CYP3A72.40.06.00.00.9N.S.11.41.00.50.0N.S.N.S.N.S.
CYP2A73.50.03.60.01.1N.S.1.3N.S.0.50.00.60.0N.S.N.S.
CYP3A43.80.014.40.01.1N.S.23.80.00.40.0N.S.N.S.N.S.
CYP2B610.50.010.70.02.11.35.60.00.30.00.50.00.75.3N.S.
CYP2A614.80.015.40.01.40.71.90.00.20.00.30.00.75.3N.S.
STEAP20.8N.S.0.60.00.9N.S.0.8N.S.N.S.1.42.4N.S.N.S.
  • FC, fold change (siCT-CITCO/siCT-DMSO or siCT-PB/siCT-DMSO); N.S., not significant; siCT, control siRNA; siCAR, anti-CAR siRNA.

  • * siCAR-CITCO/siCT-CITCO;

  • ** siCAR-PB/siCT-PB.