TABLE 2 

EC50 values of anticancer drugs in pancreatic cancer cell lines

For each drug and cell type, the table displays the median EC50 value, range of EC50 (micromolars), number of experimental determinations of EC50 performed (N), and resistance ratio (RR).

DrugPANC-1AsPC-1HPAF-IISW 1990MIA PaCa-2
EC50, −FTC (range)EC50, +FTC (range)NRREC50, −FTC (range)EC50, +FTC (range)NRREC50, −FTC (range)EC50, +FTC (range)NRREC50, −FTC (range)EC50, +FTC (range)NRREC50, −FTC (range)EC50, +FTC (range)NRR
µMµMµMµMµMµMµMµMµMµM
SN-380.71 (0.21–1.2)0.040 (0.0068–0.073)2180.27 (0.18–0.36)0.078 (0.045–0.11)23.50.21 (–)0.19 (–)11.10.018 (–)0.020 (–)10.900.021 (0.015–0.026)0.0096 (0.0071–0.012)22.1
Topotecan1.6 (0.88–2.4)0.16 (0.042–0.27)2110.51 (0.50–0.51)0.13 (0.13–0.13)23.91.5 (–)0.86 (–)11.70.11 (–)0.14 (–)10.790.11 (0.089–0.14)0.082 (0.073–0.090)21.4
Mitoxantrone0.53 (0.32–0.74)0.15 (0.10–0.19)23.71.3 (0.66–1.9)0.43 (0.24–0.61)23.01.1 (–)1.1 (–)11.00.67 (–)0.86 (–)10.780.14 (–)0.19 (–)10.74
Dinaciclib0.033 (–)0.019 (–)11.70.030 (–)0.026 (–)11.20.014 (–)0.016 (–)10.880.014 (–)0.017 (–)10.820.0090 (–)0.0090 (–)11.0
Flavopiridol0.42 (–)0.33 (–)11.30.26 (–)0.28 (–)10.930.22 (–)0.26 (–)10.850.15 (–)0.19 (–)10.790.11 (–)0.10 (–)11.1