Drug | PANC-1 | AsPC-1 | HPAF-II | SW 1990 | MIA PaCa-2 | |||||
---|---|---|---|---|---|---|---|---|---|---|
Concentration | Mean ± S.D. | Concentration | Mean ± S.D. | Concentration | Mean ± S.D. | Concentration | Mean ± S.D. | Concentration | Mean ± S.D. | |
µM | µM | µM | µM | µM | ||||||
Control | — | 1.0 ± 0.056 | — | 1.0 ± 0.032 | — | 1.0 ± 0.12 | — | 1.0 ± 0.13 | — | 1.0 ± 0.19 |
SN-38 | 0.3 | 1.8 ± 0.18 | 0.1 | 1.4 ± 0.34 | 0.1 | 0.76 ± 0.053 | 0.01 | 1.3 ± 0.17 | 0.01 | 8.3 ± 1.4 |
1 | 1.8 ± 0.28 | 0.3 | 0.94 ± 0.15 | 0.3 | 1.2 ± 0.25 | 0.03 | 1.0 ± 0.096 | 0.03 | 15 ± 1.7 | |
Topotecan | 1 | 1.7 ± 0.24 | 0.3 | 1.5 ± 0.070 | 0.3 | 0.76 ± 0.044 | 0.03 | 1.4 ± 0.11 | 0.03 | 3.1 ± 0.19 |
3 | 1.8 ± 0.18 | 1 | 0.75 ± 0.097 | 1 | 0.83 ± 0.080 | 0.1 | 0.85 ± 0.14 | 0.1 | 17 ± 0.89 | |
Mitoxantrone | 0.1 | 2.0 ± 0.15 | 0.3 | 1.3 ± 0.20 | 0.3 | 0.65 ± 0.090 | 0.1 | 0.70 ± 0.14 | 0.03 | 17 ± 1.8 |
0.3 | 1.8 ± 0.14 | 1 | 0.75 ± 0.089 | 1 | 1.2 ± 0.20 | 0.3 | 1.1 ± 0.14 | 0.1 | 20 ± 1.4 | |
Dinaciclib | 0.01 | 0.73 ± 0.018 | 0.01 | 0.98 ± 0.17 | 0.003 | 0.78 ± 0.040 | 0.003 | 0.76 ± 0.055 | 0.003 | 1.2 ± 0.17 |
0.03 | 1.9 ± 0.13 | 0.03 | 0.99 ± 0.087 | 0.01 | 1.2 ± 0.057 | 0.01 | 1.3 ± 0.19 | 0.01 | 4.1 ± 0.45 | |
Flavopiridol | 0.1 | 0.65 ± 0.094 | 0.1 | 0.97 ± 0.10 | 0.1 | 1.2 ± 0.11 | 0.03 | 0.71 ± 0.10 | 0.03 | 0.99 ± 0.085 |
0.3 | 1.2 ± 0.17 | 0.3 | 1.7 ± 0.31 | 0.3 | 1.5 ± 0.13 | 0.1 | 0.76 ± 0.12 | 0.1 | 1.7 ± 0.25 |