TABLE 1

Pharmacokinetic parameters of the radioactivity in the plasma of rats during and after 21 daily multiple oral administrations of [¹⁴C]MLN3126 at a daily dose of 10 mg at 4.71 MBq/kg

Each value represents the mean ± S.D.value for three animals.

Day	Pharmacokinetic Parameter
Day	T_max	C_max^{^a}	C_min^{^a}^,^{^b}	t_1/2	AUC_{0–24 h}^{^a}
	h	μg Eq/ml	μg Eq/ml	h	μg Eq⋅h/ml
1	1.0 ± 0.0	4.321 ± 1.351	0.845 ± 0.280	11.5 ± 0.8	48.587 ± 15.443
4	1.0 ± 0.0	5.392 ± 1.041	1.214 ± 0.337	13.1 ± 0.3	62.364 ± 16.729
7	0.7 ± 0.3	5.717 ± 0.507	1.062 ± 0.171	12.5 ± 0.4	57.117 ± 7.340
11	0.8 ± 0.3	6.857 ± 1.963	1.129 ± 0.294	12.5 ± 0.1	63.574 ± 15.484
14	0.7 ± 0.3	7.502 ± 1.195	1.349 ± 0.298	13.6 ± 0.5	70.882 ± 13.612
18	0.7 ± 0.3	5.331 ± 1.092	1.184 ± 0.302	14.1 ± 0.6	58.867 ± 15.921
21	1.0 ± 0.0	5.936 ± 1.527	1.237 ± 0.445	13.9 ± 1.1	63.425 ± 23.450

C_min, concentration 24 hours after administration; T_max, time to reach C_max.
↵^a MLN3126 equivalent.
↵^b Concentration 24 hours after administration.