TABLE 6

Predicted CL_int,u of midazolam, propranolol, and saquinavir in human hepatocytes in static and shaken incubations in comparison with predicted values from in vitro literature data and observed in vivo CL_int,u

Data represent mean ± S.D., unless otherwise indicated.

Drug	Predicted CL_int,u					Observed CL_int,u
	0.1 µM		1 µM
	Static	Shaking	Static	Shaking	Literature
	ml/min per kilogram
Midazolam	100 ± 10.4	125 ± 53.1	92.1 ± 2.14	96.6 ± 39.2	42.2^{^a}	390^{^a}
Propranolol	42.9 ± 1.52	89.2 ± 13.2^*	28.4 ± 7.64	57.5 ± 8.94^*	50.3^{^a}	333^{^a}
Saquinavir			95.2 ± 12.4	263 ± 48.1^*		3200^a

↵^a Wood et al. (2017).
↵* P < 0.05