TABLE 7 

Effect of data quality on the slope factor β

Number of Fitsβ (Average)a%CVbMincMaxc
IC50 fits from all laboratories for all data sets with tβ > 3 (Bentz et al., 2013)a
 MDCK481.3500.33.6
 Caco-2701.1310.62.4
 LLC-PK131.4640.63.3
IC50 fits from those laboratories which qualified in this work, e.g., tβ > 5d
 MDCK121.2260.71.8
 Caco-2131.0240.61.6
 LLC-PK41.291.01.2
  • a Total number of fitted data sets (tβ > 3) for the slope factor β from Bentz et al. (2013) (Supplemental Data 2 of that paper).

  • b Coefficient of variation for fitted β expressed as a percentage.

  • c Minimum and maximum values for β.

  • d These data are calculated from Table 2.