TABLE 2

CL_int of midazolam, propranolol, and saquinavir in intact (unsupplemented) rat hepatocytes and saponin-permeabilized rat hepatocytes with and without NADPH supplementation

Data are normalized to total cell number and represent the mean ± S.D. (n ≥ 3).

Drug	CL_int
	Intact (unsupplemented)	Permeabilized
	Intact (unsupplemented)	Unsupplemented	NADPH Supplemented
	µl/min per 10⁶ cells
Midazolam	257 ± 21.5	7.66 ± 6.90^*	207 ± 43.4^§
Propranolol	1050 ± 367	ND	1660 ± 375^§
Saquinavir	311 ± 118	ND	778 ± 236^*,^§§

ND, no depletion detected.
↵* P < 0.01 using paired Student’s t test in comparison with intact hepatocytes.
↵§ P < 0.05,
↵§§ P < 0.01 using paired Student’s t test in comparison with unsupplemented permeabilized hepatocytes.