CLint values and the percentage of control values, determined in the conventional depletion assay in the presence of ABT and/or Rfc
Data represents mean ± S.D. (n = 3).
| Drug | CLint (μl/min per milligram protein) | % of Control | |||||
|---|---|---|---|---|---|---|---|
| Control | ABT | Rfc | ABT + Rfc | ABT | Rfc | ABT + Rfc | |
| Atorvastatin | 42.6 ± 7.9 | 9.8 ± 0.8 | 8.1 ± 2.1 | 2.3 ± 1.4 | 23* | 19* | 5* |
| Cerivastatin | 4.9 ± 2.7 | 1.2 ± 1.2 | 5.7 ± 1.5 | 1.2 ± 1.3 | 25 | 118 | 26 |
| Clarithromycin | 9.1 ± 0.3 | 0.5 ± 0.5 | 8.2 ± 1.5 | 0.3 ± 0.3 | 6* | 90 | 4* |
| Erythromycin | 11.4 ± 2.2 | 1.4 ± 0.6 | 7.1 ± 2.0 | 0.4 ± 0.3 | 12* | 62* | 4* |
| Indinavir | 57.4 ± 13.5 | 6.4 ± 1.4 | 38.6 ± 4.9 | 5.5 ± 1.3 | 11* | 67 | 10* |
| Midazolam | 239 ± 14 | 7.1 ± 2.9 | 246 ± 36 | 8.0 ± 3.4 | 3* | 103 | 3* |
| Pitavastatin | 6.3 ± 1.1 | 0.9 ± 0.2 | 1.5 ± 0.7 | 0.4 ± 0.2 | 14* | 25* | 6* |
| Repaglinide | 24.8 ± 8.4 | 8.0 ± 2.6 | 13.5 ± 6.5 | 4.2 ± 1.7 | 32* | 54 | 17* |
| Rosuvastatin | 2.2 ± 0.5 | 2.2 ± 0.4 | 0.8 ± 0.2 | 0.8 ± 0.6 | 97 | 36* | 36* |
| Saquinavir | 73.8 ± 17.9 | 18.0 ± 3.5 | 53.2 ± 13.7 | 16.6 ± 3.1 | 24* | 72 | 22* |
| Tolbutamide | 1.83 ± 0.40 | 0.81 ± 0.44 | 1.46 ± 0.56 | 0.44 ± 0.35 | 44 | 80 | 24* |
| Valsartan | 1.5 ± 0.7 | 1.9 ± 1.7 | 0.5 ± 0.7 | 0.09 ± 0.02 | 125 | 33 | 6 |
* P value of <0.05 using Scheffe’s test following analysis of variance.