TABLE 3

Summary of uptake, metabolism, distribution and binding parameters calculated using a mechanistic model

Results are displayed as the mean ± S.D. (n = 3).

DrugCLmetCLuptakeCLactiveCLpassive% of
Active TransportVcell,appKpKpufucell
μl/min per milligram protein μl/mg of protein
Atorvastatin34.0 ± 9.7208 ± 34.2183 ± 33.525.1 ± 7.1881.0 ± 0.365.08.30.128
Cerivastatin4.8 ± 2.7167 ± 67.8136 ± 66.630.8 ± 12.682386 ± 2872545.40.021
Clarithromycin8.7 ± 0.546.3 ± 9.526.3 ± 8.720.0 ± 3.857130 ± 8.873.52.30.031
Erythromycin12.4 ± 4.048.4 ± 8.628.9 ± 7.619.5 ± 4.06024.8 ± 20.816.42.50.151
Indinavir52.5 ± 9.7143 ± 41.287.0 ± 38.656.1 ± 14.6613.6 ± 5.53.82.60.666
Pitavastatin6.7 ± 1.1150 ± 56.4125 ± 55.025.2 ± 12.58360.9 ± 33.481.25.90.073
Repaglinide25.8 ± 10.695.8 ± 19.059.2 ± 17.936.7 ± 6.36252.1 ± 31.535.12.60.074
Rosuvastatin2.3 ± 0.5207 ± 64.3161 ± 61.246.5 ± 19.87854.8 ± 15.224.14.50.185
Saquinavir139 ± 40.91160 ± 919777 ± 866383 ± 30767256 ± 1882213.00.014
Valsartan2.2 ± 0.621.3 ± 3.318.1 ± 3.33.2 ± 0.58531.1 ± 6.925.66.70.263