TABLE 1

CL_int values and the percentage of control values, determined in the media loss assay in the presence of ABT and/or Rfc

Data represents mean ± S.D. (n = 3).

Drug	CL_int (μl/min per milligram protein)				% of Control
Drug	Control	ABT	Rfc	ABT + Rfc	ABT	Rfc	ABT + Rfc
Atorvastatin	120 ± 18.9	45.9 ± 7.0	7.1 ± 4.8	4.6 ± 1.0	38*	6*	4*
Cerivastatin	47.1 ± 13.9	30.7 ± 16.5	15.0 ± 2.2	9.7 ± 3.0	65	32*	21*
Clarithromycin	16.2 ± 3.4	7.2 ± 2.4	17.8 ± 3.0	5.0 ± 3.4	45*	110	31*
Erythromycin	16.2 ± 6.7	5.1 ± 1.4	13.1 ± 4.4	3.9 ± 1.5	32*	81	24*
Indinavir	80.4 ± 17.5	12.2 ± 3.3	56.4 ± 22.1	10.9 ± 4.6	15*	70	14*
Midazolam	231 ± 67	32.3 ± 6.5	288 ± 28	33.3 ± 12.2	14*	125	14*
Pitavastatin	32.5 ± 1.3	15.1 ± 9.0	2.1 ± 1.8	1.9 ± 1.6	46*	7*	6*
Repaglinide	44.2 ± 11.3	11.8 ± 0.4	17.1 ± 6.8	7.6 ± 3.2	27*	39*	17*
Rosuvastatin	6.5 ± 5.2	6.5 ± 3.4	1.3 ± 0.9	1.3 ± 0.4	99	19	20
Saquinavir	112 ± 28	33.3 ± 13.3	97.1 ± 28.4	28.1 ± 9.3	30*	87	25*
Tolbutamide	0.85 ± 0.39	0.84 ± 0.52	1.61 ± 0.47	0.87 ± 0.48	99	189	102
Valsartan	5.8 ± 3.2	8.0 ± 2.6	1.7 ± 0.5	1.7 ± 1.0	137	29	29