Kinetics of TOL metabolism with CYP2C11-null or WT rat liver microsomes
All values are shown as the mean ± S.D., n = 3. **P < 0.001 compared with that of WT rats.
| Km | Vmax | CLint | |
|---|---|---|---|
| μM | pmol/min/mg protein | μL/mg/min | |
| Null | 893.37 ± 25.15** | 1082.40 ± 30.48** | 1211.59** |
| WT | 605.76 ± 13.84 | 1384.68 ± 31.63 | 2285.86 |
CLint, intrinsic clearance.