Cisplatin-induced toxicity is independent of MATE-mediated transport in ciPTEC-parent, ciPTEC-OAT1, and ciPTEC-OAT3
TC50 values (represented in micromolar) calculated from MTT viability assays following cisplatin (8.7–222 μM) exposure for 24 h are not affected by competitive MATE inhibition (pyrimethamine, 10 and 100 nM) in ciPTEC-parent, ciPTEC-OAT1, and ciPTEC-OAT3 (mean TC50, n = 2).
| Control | Pyrimethamine | ||
|---|---|---|---|
| 10 nM | 100 nM | ||
| ciPTEC-parent | 41 | 45 | 46 |
| ciPTEC-OAT1 | 59 | 57 | 57 |
| ciPTEC-OAT3 | 103 | 111 | 136 |