Control | Rifampicin Treated | Rifampicin Treated/Control (%) | |
---|---|---|---|
AUC0‒60 min, blood (%dose⋅min per milliliter) | 0.103 ± 0.020 | 0.180 ± 0.061** | 174.8 |
AUC0‒60 min, liver (%dose⋅min per gram of tissue) | 1.02 ± 0.11 | 0.263 ± 0.034*** | 25.8 |
AUC0‒60 min, kidney (%dose⋅min per gram of tissue) | 0.656 ± 0.197 | 0.906 ± 0.259 | 138.1 |
CLuptake, liver (ml/min per kilogram) | 11.4 ± 4.0 | 5.18 ± 3.81** | 45.4 |
VE, liver (ml/kg) | 4.45 ± 0.63 | 4.07 ± 0.84 | 91.5 |
CLuptake, kidney (ml/min per kilogram) | 7.83 ± 3.26 | 5.72 ± 3.80 | 73.1 |
VE, kidneys (ml/kg) | 5.49 ± 0.67 | 5.44 ± 0.47 | 99.1 |
CLint, bile (ml/min per kilogram) | 0.221 ± 0.083 | 0.129 ± 0.091* | 58.4 |
AUC0‒60 min, blood, AUC for blood from 0 to 60 min; AUC0‒60 min, kidney, AUC for kidney from 0 to 60 min; AUC0–60 min, liver before AUC for liver from 0 to 60 min; VE, kidneys, VE in the kidneys; VE, liver, VE in the liver.
↵* P < 0.05;
↵** P < 0.01;
↵*** P < 0.0001, statistical significance was tested by Student’s two-tailed paired t test.